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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Idiopathic factor V inhibitor in a patient starting haemodialysis

Luke J Sutherland1, Sarah Tan1, Merit Hanna1

  • 1Department of Medicine, North Shore Hospital, Auckland, New Zealand.

Internal Medicine Journal
|April 4, 2022
PubMed

A 74-year-old Pacific Island man with end-stage renal failure planning to start haemodialysis presented with persistent bleeding after tunnelled dialysis catheter insertion. The laboratory findings revealed a prolonged activated partial thromboplastin time of 118 s, prothrombin ratio of 4.2, factor V activity of <2% and a factor V inhibitor of 40 Bethesda Units. No clear underlying aetiology was identified. The bleeding settled with conservative measures and the factor V inhibitor was successfully treated with oral cyclophosphamide for 6 weeks.

Keywords:
factor Vhaemodialysisinhibitor

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