Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hepatic Drug Excretion: Enterohepatic Cycling01:17

Hepatic Drug Excretion: Enterohepatic Cycling

1.9K
Enterohepatic cycling involves the active secretion of drugs and their metabolites into the bile via transporters in the canalicular membrane of hepatocytes. This secretion is an integral part of the digestive process, releasing these substances into the gastrointestinal (GI) tract.
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
1.9K
Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

252
The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
252
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

174
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
174

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute pancreatitis secondary to severe hypertriglyceridemia induced by antiretroviral therapy.

Revista espanola de enfermedades digestivas·2024
Same author

Acute hepatitis secondary to febuxostat.

Revista espanola de enfermedades digestivas·2023
Same author

Biliary obstruction secondary to duodenal follicular lymphoma with papillary involvement.

Revista espanola de enfermedades digestivas·2023
Same author

Endoscopic ultrasound guided diagnosis of a retroperitoneal extra-gastrointestinal stromal tumor.

Revista espanola de enfermedades digestivas·2023
Same author

DRESS syndrome secondary to carbamazepine.

Revista espanola de enfermedades digestivas·2022
Same author

Adrenal insufficiency and hepatic cirrhosis: a relationship to discover.

Revista espanola de enfermedades digestivas·2022

Related Experiment Video

Updated: Sep 28, 2025

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

3.1K

Cefditoren-induced hepatitis.

Javier Miguel Martín Guerra1, Miryam Moreta Rodríguez2

  • 1Medicina Interna, Hospital Clínico Universitario de Valladolid, España.

Revista Espanola De Enfermedades Digestivas
|April 4, 2022
PubMed
Summary

Daily antibiotic prescriptions, particularly beta-lactams for common infections like cystitis, can cause drug-induced liver injury. Recognizing and stopping these medications is crucial for patient safety during hepatotoxicity diagnosis.

More Related Videos

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

19.4K
Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.5K

Related Experiment Videos

Last Updated: Sep 28, 2025

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

3.1K
The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

19.4K
Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.5K

Area of Science:

  • Pharmacology
  • Hepatology
  • Infectious Diseases

Background:

  • Beta-lactam antibiotics are frequently prescribed for common infections, including urinary tract infections like cystitis in young women.
  • These widely used antibiotics possess an inherent risk of causing drug-induced liver injury (DILI).

Discussion:

  • Hepatotoxicity from beta-lactams often presents with non-specific symptoms and elevated liver enzymes (transaminases).
  • Clinicians must consider antibiotic-induced hepatotoxicity in the differential diagnosis of liver dysfunction.
  • Prompt discontinuation of the suspected antibiotic is essential upon recognition of liver injury.

Key Insights:

  • Beta-lactam antibiotics pose a risk of hepatotoxicity, even in seemingly minor infections.
  • Elevated transaminases are a key indicator of potential drug-induced liver injury.
  • Early identification and cessation of offending antibiotics are critical for managing hepatotoxicity.

Outlook:

  • Further research into predicting and mitigating beta-lactam-induced hepatotoxicity is warranted.
  • Enhanced awareness among healthcare providers can improve diagnostic accuracy and patient outcomes.
  • Developing safer antibiotic alternatives or treatment strategies remains an important goal.