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Analysis of acid-base disorders in an ICU cohort using a computer script
Innas Forsal1, Mikael Bodelsson2, Anders Wieslander1
1Baxter Gambro Lundia, Magistratsvägen 16, 22643, Lund, Sweden.
Intensive Care Medicine Experimental
|April 4, 2022
Summary
An automated script accurately assesses acid-base status in critically ill patients, improving upon manual calculations. This tool aids in diagnosing and monitoring complex acid-base disturbances more efficiently.
Area of Science:
- Critical care medicine
- Biochemistry
- Medical informatics
Background:
- Accurate acid-base status assessment is vital for critically ill patients.
- Manual calculations are time-consuming and prone to errors.
- Automated assessment can improve diagnostic accuracy and patient management.
Purpose of the Study:
- To develop and evaluate an automated script for acid-base status assessment.
- To compare automated calculations with manual methods in intensive care unit (ICU) patients.
- To analyze the prevalence and types of acid-base disturbances in a large patient cohort.
Main Methods:
- A simplified adaptive MATLAB script was developed.
- The script processed blood gas analyses from ICU admissions.
- Automated results were compared against manual calculations by experienced physicians.
Main Results:
- The script demonstrated complete correlation with manual calculations.
- Analysis of 8875 admissions revealed 46.3% normal acid-base status.
- Respiratory acidosis (31.0%) and alkalosis (17.0%) were the most common primary disturbances, with frequent mixed disorders (74.7%).
Conclusions:
- Existing acid-base theories may not perfectly apply to critically ill patients.
- The Boston/Copenhagen model proved more effective for script development than the Stewart model.
- Acidoses were more prevalent and severe than alkaloses in the studied cohort.
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