Gossypetin- based therapeutics for cognitive dysfunction in chronic unpredictable stress- exposed mice
Nikita Patil Samant1, Girdhari Lal Gupta2,3,4
1Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM'S NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, 400 056, Maharashtra, India.
Metabolic Brain Disease
|April 4, 2022
Summary
Gossypetin shows neuroprotective effects against chronic stress-induced cognitive impairment by modulating the kynurenine pathway. This natural compound improved memory and reduced stress markers in mice.
Area of Science:
- Neuroscience
- Pharmacology
- Biochemistry
Background:
- Chronic unpredictable stress (CUS) induces cognitive impairment, linked to kynurenine pathway activation.
- This pathway involves cortisol, microglia activation, and increased quinolinic acid, impairing brain-derived neurotrophic factor (BDNF) and causing neurodegeneration.
- Gossypetin possesses known antioxidant and antidepressant properties.
Purpose of the Study:
- To investigate the neuroprotective potential of gossypetin against CUS-induced cognitive deficits.
- To explore gossypetin's mechanism of action via the kynurenine pathway.
Main Methods:
- Swiss albino mice were subjected to CUS for five weeks.
- Gossypetin (5, 10, 20 mg/kg) was administered from week 4 to 7.
- Behavioral tests, corticosterone, neurotransmitter, oxidative stress, and BDNF levels were measured.
Main Results:
- Gossypetin treatment significantly improved behavioral patterns in CUS-exposed mice.
- Gossypetin (10 and 20 mg/kg) reduced corticosterone levels and oxidative stress.
- Serotonin, norepinephrine, and BDNF levels increased following gossypetin administration.
Conclusions:
- Gossypetin demonstrates significant neuroprotective activity against CUS-induced cognitive impairment.
- Gossypetin's effects are mediated through modulation of the kynurenine pathway.
- Gossypetin holds promise as a therapeutic agent for stress-related cognitive dysfunction.
