Review of Open Cavity Random Lasers as Laser-Based Sensors

In this review, the concept of open cavity lasing for ultrasensitive sensing is explored, specifically in driving important innovations as laser-based biosensors─a field mostly dominated by fluorescence-based sensing. Laser-based sensing exhibits higher signal amplification and lower signal-to-noise ratio due to narrow emission lines as well as high sensitivity due to nonlinear components. The versatility of open cavity random lasers for probing analytes directly which is ultrasensitive to small changes in chemical composition and temperature fluctuations paves the path of utilizing narrow emission lines for advanced sensing. The concept of random lasing is first explained followed by a comparison of the different lasing threshold that has been reported. This is followed by a survey of reports on laser-based sensing and more specifically as biosensors. Finally, a perspective on the way forward for open cavity laser-based sensing is put forth.