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BHPF exposure impairs mouse and human decidualization.

Zhi-Yong Jin1, Cheng-Kan Liu1, Yu-Qi Hong1

  • 1College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.

Environmental Pollution (Barking, Essex : 1987)
|April 4, 2022
PubMed
Summary
This summary is machine-generated.

Bisphenol AF (BHPF) exposure harms early pregnancy in mice and humans. BHPF disrupts decidualization and embryonic development, impacting reproductive health.

Keywords:
BHPFCollagenDecidualizationEmbryonic developmentLamin B1

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Area of Science:

  • Reproductive toxicology
  • Developmental biology
  • Endocrinology

Background:

  • Bisphenol AF (BHPF) is a BPA substitute in plastics.
  • Emerging evidence suggests BHPF poses reproductive risks.
  • Its impact on early mammalian pregnancy requires further investigation.

Purpose of the Study:

  • To investigate BHPF's effects on early pregnancy, focusing on decidualization and embryonic development.
  • To explore the underlying molecular mechanisms in both mouse and human models.

Main Methods:

  • Animal studies using mice exposed to BHPF.
  • In vitro decidualization assays using mouse and human cells.
  • Analysis of gene and protein expression, including Lamin B1, collagen, and the HB-EGF/EGFR/STAT3 pathway.

Main Results:

  • BHPF exposure reduced birth weight and implantation site weight in mice.
  • BHPF inhibited both embryo development and artificial decidualization in mice.
  • In vitro, BHPF disrupted decidualization and altered collagen and Lamin B1 expression in both mouse and human cells.
  • Collagen III supplementation partially rescued BHPF's inhibitory effect on human decidualization.
  • BHPF impairs human decidualization via the HB-EGF/EGFR/STAT3/Collagen III pathway.

Conclusions:

  • BHPF exposure negatively impacts early pregnancy outcomes in mice.
  • BHPF interferes with critical processes of decidualization and embryonic development.
  • The study elucidates a specific molecular pathway through which BHPF disrupts human decidualization.
  • These findings highlight potential risks associated with BHPF exposure during early pregnancy.