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Updated: Aug 19, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
[Clinical evaluation of Chymodiactin and post-marketing surveillance]
Abstract:
After a short summary of the development of chemonucleolysis technique and of Chymodiactin, the result of a randomized double-blind placebo controlled trial, conducted in the USA with Chymodiactin in 108 patients with monosegmental lumbar disc hernia and an open multicentre-study in 1498 patients, are shown. Furthermore an interim evaluation is presented of an open controlled multicentre-study with Chymodiactin, started in Germany in 1983. The results of these three clinical studies as well as the post-marketing surveillance pending in the USA demonstrate that chemonucleolysis with Chymodiactin is a secure technique with good results, representing a valuable enrichment in the treatment of lumbar herniated nucleus pulposus.
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