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Related Experiment Video

Updated: Sep 28, 2025

Assessment of Kidney Function in Mouse Models of Glomerular Disease
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Assessment of Kidney Function in Mouse Models of Glomerular Disease

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A translational rat model to assess glomerular function changes with vancomycin.

Gwendolyn M Pais1, Jack Chang1, Jiajun Liu1

  • 1Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, USA; Midwestern University Chicago College of Pharmacy Pharmacometrics Center of Excellence, Downers Grove, IL, USA.

International Journal of Antimicrobial Agents
|April 4, 2022
PubMed
Summary
This summary is machine-generated.

Vancomycin (VAN) rapidly reduces kidney function, as measured by glomerular filtration rate (GFR), immediately after the first dose in rats. This decline correlates with kidney VAN levels and elevated injury biomarkers.

Keywords:
FITC-sinistrinKIM-1RatTransdermal GFRUrinary biomarkerVancomycin

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Area of Science:

  • Nephrology
  • Pharmacology
  • Translational Medicine

Background:

  • Vancomycin (VAN) is crucial for treating infections but can cause kidney injury.
  • Serum creatinine (SCr) is a common but delayed indicator of kidney function decline.
  • Glomerular filtration rate (GFR) provides a more immediate assessment of kidney function.

Purpose of the Study:

  • To investigate the rate and extent of GFR changes following VAN administration in a rat model.
  • To compare GFR decline with kidney VAN accumulation and urinary biomarkers of injury.

Main Methods:

  • Male Sprague Dawley rats received daily intravenous VAN (150 mg/kg) or saline for 3 days.
  • GFR was measured using fluorescein isothiocyanate-sinistrin (FITC-sinistrin) clearance.
  • Urinary biomarkers (KIM-1, clusterin) and kidney VAN concentrations were analyzed.

Main Results:

  • VAN treatment significantly reduced GFR starting from Day 1, compared to saline controls (P ≤ 0.05).
  • Elevated KIM-1 and clusterin levels were observed on Day 1 in VAN-treated rats.
  • GFR decline and biomarker elevation correlated with kidney VAN accumulation (R² = 0.6 and R² = 0.9, respectively).

Conclusions:

  • VAN causes an immediate decline in GFR in rats, preceding significant SCr changes.
  • Kidney VAN concentration is a key factor in VAN-induced GFR reduction and biomarker changes.
  • This model demonstrates a rapid functional assessment of VAN nephrotoxicity.