Related Experiment Video
Updated: Sep 28, 2025
11:31
Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
Published on: November 30, 2015
16.2K
Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms
Eshim S Jami1, Anke R Hammerschlag2, Hill F Ip3
1Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; University College London, London, United Kingdom.
Summary
Childhood internalizing symptoms have low overall heritability but significant genetic links to adult disorders. Self-reports reveal higher genetic influence, suggesting shared vulnerabilities and informing future genetic studies.
Area of Science:
- Psychiatric Genetics
- Developmental Psychology
- Behavioral Genetics
Background:
- Internalizing symptoms are common in childhood and adolescence.
- Understanding their genetic basis is crucial for explaining persistence and comorbidity.
Purpose of the Study:
- To investigate the genetic architecture of internalizing symptoms in youth.
- To identify genetic links between childhood internalizing symptoms and other psychiatric traits.
Main Methods:
- Conducted genome-wide association studies (GWASs) across 22 cohorts totaling 64,561 individuals (ages 3-18).
- Performed meta-analyses of internalizing symptoms, accounting for sample overlap and stratifying by rater, age, and instrument.
- Calculated genetic correlations with adult and childhood psychiatric conditions.
Main Results:
- Overall single nucleotide polymorphism (SNP) heritability for internalizing symptoms was low (1.66%).
- Self-reported symptoms showed higher heritability (5.63%), indicating rater-based heterogeneity.
- Significant genetic correlations were found with adult anxiety, depression, and various childhood disorders (e.g., ADHD, aggression).
Conclusions:
- Childhood internalizing symptoms share genetic vulnerabilities with adult internalizing disorders and other psychiatric traits.
- These shared genetic factors may explain symptom persistence and high comorbidity.
- Reducing phenotypic heterogeneity in samples is essential for future GWAS success.
Related Concept Videos
01:28Human Genetics
765
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
765
01:23Behavioral Genetics and Its Designs
575
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
575
01:30Attention-Deficit/Hyperactivity Disorder
401
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
401
01:11Genome-wide Association Studies-GWAS
14.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.5K
01:27Depressive Disorders: Etiology
176
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
176
01:30Generalized Anxiety Disorder
231
Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
231