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Updated Pharmacological Effects of Total Phenolic Acid on the Meningeal Microcirculation in Mice
Hui Zhao1,2, Jiaojiao Jia2, Ming Bai2
1Department of Pharmacology, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Objective:
To investigate the effects of total phenolic acid on meningeal microcirculation in mice.
Methods:
A total of 84 healthy mice were randomly divided into the blank group, the model group, the positive control Western medicine group, the positive control Chinese medicine group, and the large, medium, and small doses of the total phenolic acid group, with 12 rats in each group. The corresponding drug was given to the group once a day for one week, and the litter was changed at 9 : 00 on the 6th day, and the water fasted. On the 7th day, the groups continued to be administered and weighed. After 1 h, the percentage of decrease in the perfusion of the mice was measured.
Results:
Compared with the blank group, the percentage of perfusion decreased significantly in the model group, indicating that the model was successful. Compared with the model group, the nimodipine group, the Naoluotong group, and the high-dose succulent total phenolic acid group were perfused. The percentage of decrease was significantly decreased (P < 0.01), and the percentage of perfusion decreased in the middle and small doses of the total phenolic acid group (P < 0.05), indicating that the percentage of mice perfused decreased by the administration of each group.
Conclusion:
Total phenolic acid can reduce the percentage of mean perfusion of microcirculation in animals and reduce brain damage.
