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Vesicular Approach Review on Nanocarriers bearing Curcumin and Applications.
Prashant Upadhyay1, Deepak Singh1, Sukirti Upadhyay1
1School of Pharmaceutical Sciences, Faculty of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, India.
Recent Advances in Drug Delivery and Formulation
|April 5, 2022
Summary
Vesicular nanocarriers enhance the bioavailability of poorly water-soluble phytoconstituents. This review explores various vesicular systems for targeted drug delivery, improving stability and permeability.
Area of Science:
- Pharmaceutical Sciences
- Nanotechnology
- Drug Delivery Systems
Background:
- Phytoconstituents offer therapeutic potential but are limited by poor aqueous solubility.
- Vesicular systems are developed to overcome bioavailability and efficacy challenges of poorly water-soluble drugs.
- Targeted delivery is crucial for maximizing therapeutic benefits and minimizing side effects.
Purpose of the Study:
- To review and contrast various vesicular nanocarrier systems for drug delivery.
- To focus on the preparation, characterization, drug release, and market trends of these nanocarriers.
- To illustrate the applications, advantages, and disadvantages of vesicular systems using curcumin as a model.
Main Methods:
- Comprehensive literature review of vesicular drug delivery systems.
- Analysis of preparation and characterization techniques for nanocarriers.
- Evaluation of drug release profiles and administration routes.
Main Results:
- Numerous vesicular systems (liposomes, niosomes, ethosomes, phytosomes, etc.) have been developed.
- These systems demonstrate potential for improving drug stability, permeability, and targeted delivery.
- Curcumin-loaded nanocarriers show promise in gene delivery, brain tumor targeting, and oral formulations.
Conclusions:
- Vesicular nanocarriers represent a significant advancement in pharmaceutical drug delivery.
- They offer solutions for challenges associated with poorly water-soluble drugs like curcumin.
- Further research into market scenarios and future trends is essential for clinical translation.
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