Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

255
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
255
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

343
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
343
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

216
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
216
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

477
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
477
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

276
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
276
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

481
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
481

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular and Functional Characterization of RecD, a Novel Member of the SF1 Family of Helicases, from Mycobacterium tuberculosis.

The Journal of biological chemistry·2015
See all related articles

Related Experiment Video

Updated: Sep 28, 2025

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

18.9K

Drug resistant tuberculosis: Current scenario and impending challenges.

Shivendra Singh Dewhare1

  • 1School of Studies in Life Science, Pt. RavishankarShukla University, Raipur, 492010, Chhattisgarh, India.

The Indian Journal of Tuberculosis
|April 5, 2022
PubMed
Summary

Tuberculosis remains a global health threat due to drug-resistant strains. This review explores novel drug actions, resistance mechanisms, and vaccines to combat Mycobacterium tuberculosis effectively.

Keywords:
DrugMDR-TBMycobacteriaTuberculosisVaccine

More Related Videos

Matrix-based DNA Extraction for Targeted Next-Generation Sequencing on Decontaminated Sputum Samples
06:07

Matrix-based DNA Extraction for Targeted Next-Generation Sequencing on Decontaminated Sputum Samples

Published on: June 6, 2025

424
System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

8.7K

Related Experiment Videos

Last Updated: Sep 28, 2025

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

18.9K
Matrix-based DNA Extraction for Targeted Next-Generation Sequencing on Decontaminated Sputum Samples
06:07

Matrix-based DNA Extraction for Targeted Next-Generation Sequencing on Decontaminated Sputum Samples

Published on: June 6, 2025

424
System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

8.7K

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Tuberculosis (TB) persists as a leading global cause of death, challenging current treatments.
  • Mycobacterium tuberculosis exhibits remarkable persistence, complicating eradication efforts.
  • The emergence of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) necessitates new therapeutic strategies.

Purpose of the Study:

  • To review current understanding of drug mechanisms and resistance in Mycobacterium tuberculosis.
  • To examine novel drug molecules, traditional drug actions, and emerging resistance pathways.
  • To assess recent advancements in TB vaccination strategies for disease containment.

Main Methods:

  • Literature review of existing research on tuberculosis drug action and resistance.
  • Analysis of molecular mechanisms underlying drug efficacy and failure.
  • Evaluation of data on novel vaccine candidates and their potential impact.

Main Results:

  • Detailed review of novel and traditional anti-TB drug modes of action.
  • Exploration of molecular mechanisms contributing to drug resistance in M. tuberculosis.
  • Assessment of promising new vaccination strategies showing potential for TB control.

Conclusions:

  • Understanding drug mechanisms and resistance is crucial for developing effective TB therapies.
  • Novel drug development and vaccination approaches hold significant promise for TB eradication.
  • Integrated strategies combining new drugs and vaccines are essential for global TB containment.