Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

7.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
7.6K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

5.0K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
5.0K
Antigen Presenting Cells01:22

Antigen Presenting Cells

2.2K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
2.2K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

6.6K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
6.6K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.6K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

729
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
729

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delivery of DNA-encoded vaccines and proteins in mice using cutaneous suction-mediated transfection.

FEBS open bio·2026
Same author

Conformational variants of I-A<sup>k</sup> MHC class II molecules carry distinct immunopeptidomes.

Molecular immunology·2025
Same author

Assessments of working group effectiveness in the planning of the New Jersey Kids Study: An applied mixed-methods study on the science of team science.

Journal of clinical and translational science·2024
Same author

The MHC Class II Antigen-Processing and Presentation Pathway Is Dysregulated in Type 1 Diabetes.

Journal of immunology (Baltimore, Md. : 1950)·2023
Same author

A SARS-CoV-2 Vaccine Designed for Manufacturability Results in Unexpected Potency and Non-Waning Humoral Response.

Vaccines·2023
Same author

Zbtb20 identifies and controls a thymus-derived population of regulatory T cells that play a role in intestinal homeostasis.

Science immunology·2022

Related Experiment Video

Updated: Sep 28, 2025

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

15.5K

B cells masquerade as dendritic cells.

Lisa K Denzin1

  • 1Child Health Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, 89 French Street, Room 4272 CHINJ, New Brunswick, NJ 08901, USA.

Trends in Immunology
|April 5, 2022
PubMed
Summary

Marginal zone B cells (MZBs) steal MHC class II (MHCII) from dendritic cells (DCs) during complement-dependent reactions. This interaction may allow MZBs to uniquely regulate T cell activation.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Marginal zone B cells (MZBs) are crucial immune cells residing in the spleen.
  • Dendritic cells (DCs) are professional antigen-presenting cells vital for initiating adaptive immune responses.

Purpose of the Study:

  • To investigate the interaction between MZBs and DCs regarding MHC class II (MHCII) transfer.
  • To understand the functional consequences of MHCII transfer from DCs to MZBs on T cell activation.

Main Methods:

  • Utilized complement-dependent reactions to study cell interactions.
  • Analyzed the transfer of MHCII molecules between cell types.

Main Results:

  • Demonstrated that MZBs actively acquire MHCII from DCs.
  • Showed this transfer occurs in a complement-dependent manner.

More Related Videos

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

20.6K
Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus
09:04

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus

Published on: March 28, 2025

436

Related Experiment Videos

Last Updated: Sep 28, 2025

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

15.5K
Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

20.6K
Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus
09:04

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus

Published on: March 28, 2025

436
  • Highlighted the potential for MZBs to influence T cell activation through stolen MHCII.

    • Conclusions:

    • MZBs can acquire MHCII from DCs, suggesting a novel mechanism for immune regulation.
    • This process may lead to distinct T cell activation patterns compared to DC-mediated activation.