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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

919
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
919
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

717
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
717

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Related Experiment Video

Updated: Sep 28, 2025

A Standardized Obstacle Course for Assessment of Visual Function in Ultra Low Vision and Artificial Vision
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Development and validation of the 40-item Glaucoma Visual Functioning Questionnaire.

Haishun Huang1, Junxiong Lin1, Man Luo1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China.

The British Journal of Ophthalmology
|April 5, 2022
PubMed
Summary
This summary is machine-generated.

The Glaucoma Visual Functioning Questionnaire-40 (GVFQ-40) demonstrates strong validity and reliability in Chinese glaucoma patients, effectively measuring visual ability and aiding in intervention assessment.

Keywords:
GlaucomaRehabilitationVision

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Area of Science:

  • Ophthalmology
  • Psychometrics
  • Vision Science

Background:

  • Glaucoma is a leading cause of irreversible vision loss worldwide.
  • Assessing the impact of glaucomatous vision impairment on daily functioning is crucial for patient care.
  • Existing visual functioning questionnaires may not fully capture the nuances of visual ability in diverse populations.

Purpose of the Study:

  • To evaluate the psychometric properties of the newly developed 40-item Glaucoma Visual Functioning Questionnaire (GVFQ-40).
  • To assess the validity and reliability of the GVFQ-40 in a Chinese sample of glaucoma patients and controls.
  • To determine the GVFQ-40's ability to capture visual functioning across five domains in glaucomatous vision impairment.

Main Methods:

  • A cross-sectional, observational study involving 270 glaucoma patients and 84 glaucoma suspects (controls).
  • Subjects completed the GVFQ-40 and the National Eye Institute Visual Functioning Questionnaire-25 (NEI VFQ-25).
  • Psychometric properties including discriminant, criterion-related, and construct validity were assessed. Test-retest reliability was evaluated in a subset.

Main Results:

  • Glaucoma patients reported significantly worse visual ability (higher GVFQ-40 scores) compared to controls across most domains (p<0.001).
  • GVFQ-40 scores showed strong correlations with objective measures of glaucoma severity (mean deviation, Visual Field Index).
  • The GVFQ-40 demonstrated high test-retest reliability (intraclass correlation coefficients > 0.927).

Conclusions:

  • The GVFQ-40 is a valid and reliable instrument for assessing visual functioning in Chinese glaucoma patients.
  • The questionnaire effectively captures the impact of glaucomatous vision impairment.
  • The GVFQ-40 shows potential for evaluating the efficacy of interventions aimed at improving visual ability in glaucoma.