Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Solubility of Ionic Compounds02:55

Solubility of Ionic Compounds

64.5K
Solubility is the measure of the maximum amount of solute that can be dissolved in a given quantity of solvent at a given temperature and pressure. Solubility is usually measured in molarity (M) or moles per liter (mol/L). A compound is termed soluble if it dissolves in water.
64.5K
Solubility Equilibria03:07

Solubility Equilibria

53.5K
Solubility equilibria are established when the dissolution and precipitation of a solute species occur at equal rates. These equilibria underlie many natural and technological processes, ranging from tooth decay to water purification. An understanding of the factors affecting compound solubility is, therefore, essential to the effective management of these processes. This section applies previously introduced equilibrium concepts and tools to systems involving dissolution and precipitation.
The...
53.5K
Solvating Effects02:12

Solvating Effects

7.9K
An understanding of the solvating effect helps rationalize the relation between solvation and acidity of the compound. In addition, this also explains the relative stability of conjugate bases for compounds with different pKa values. This lesson details, in-depth, the principle of solvating effects. The strength of an acid and the stability of its corresponding conjugate base are determined using pKa values. This observed relationship is a consequence of solvation, which is the interaction...
7.9K
Solubility Equilibria: Overview01:09

Solubility Equilibria: Overview

936
When a substance such as sodium chloride is added to water, it dissolves, forming an aqueous solution. The extent of dissolution is called solubility. The process of dissolution can exist in equilibrium, just like other chemical processes. Solubility equilibria are also called precipitation equilibria because the process of solubility can be reversible. The reverse of the solubility process is called precipitation.
Solubility is important in biological and environmental processes. A notable...
936
Chemical and Solubility Equilibria02:21

Chemical and Solubility Equilibria

4.3K
The free energy change associated with dissolving a solute in a liter of solvent is called the free energy of a solution, ΔGsolution. The overall ΔGsolution is expressed as the balance of ΔGinteraction against the always-favorable free-energy of mixing, ΔGmixing. Solution formation is favorable if  ΔGsolution is less than zero, whereas it is unfavorable if ΔGsolution is greater than zero. In short, for a solution to form and complete dissolution to take place,...
4.3K
Physical Properties Affecting Solubility02:19

Physical Properties Affecting Solubility

23.9K
Solutions of Gases in Liquids
As for any solution, the solubility of a gas in a liquid is affected by the attractive intermolecular forces between solute and solvent species. Unlike solid and liquid solutes, however, there is no solute-solute intermolecular attraction to overcome when a gaseous solute dissolves in a liquid solvent since the atoms or molecules comprising a gas are far separated and experience negligible interactions. Consequently, solute-solvent interactions are the sole...
23.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing Precision Oncology: Structural Frameworks for Local MTB Integration and Outcome Assessment.

Medical sciences (Basel, Switzerland)·2026
Same author

Exploring the Properties of Organometallic Lactone-Containing Poly(benzofuran-co-arylacetic Acid): Traditional Synthesis Versus Mechanosynthesis.

Polymers·2025
Same author

Biological Models for Evaluating Hydrogel-Based Formulations in Wound Healing.

Gels (Basel, Switzerland)·2025
Same author

Pharmaceutical Co-crystal of Ketoconazole-adipic Acid: Excipient Compatibility and In Silico Antifungal Potential Studies.

Pharmaceutical research·2025
Same author

Composite Materials Based on Biochar Obtained from Tomato Wastes and Fe<sub>3</sub>O<sub>4</sub>/MnO<sub>2</sub> Used for Paracetamol Adsorption.

Materials (Basel, Switzerland)·2025
Same author

Development and Preclinical Evaluation of Fixed-Dose Capsules Containing Nicergoline, Piracetam, and Hawthorn Extract for Sensorineural Hearing Loss.

Pharmaceutics·2025

Related Experiment Video

Updated: Sep 28, 2025

Crystallization of Membrane Proteins in Lipidic Mesophases
11:53

Crystallization of Membrane Proteins in Lipidic Mesophases

Published on: March 28, 2011

31.5K

Structural studies of various olmesartan solvates.

Ioana Georgeta Grosu1, Flavia Martin1, Alexandru Turza2

  • 1Molecular and Biomolecular Physics, National Institute for R&D of Isotopic and Molecular Technologies, Donat 67-103, PO 5 Box 700, 400293 Cluj-Napoca, Romania.

Acta Crystallographica. Section C, Structural Chemistry
|April 5, 2022
PubMed
Summary

Seven new solvates of olmesartan, an angiotensin II receptor blocker, were synthesized and characterized. Crystal structures reveal specific intermolecular interactions, offering insights into drug formulation and stability.

Keywords:
angiotensin II receptor blocker agentcrystal structureisostructuralolmesartansolid form

More Related Videos

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.2K
Synthesis and Characterization of Functionalized Metal-organic Frameworks
11:27

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

48.4K

Related Experiment Videos

Last Updated: Sep 28, 2025

Crystallization of Membrane Proteins in Lipidic Mesophases
11:53

Crystallization of Membrane Proteins in Lipidic Mesophases

Published on: March 28, 2011

31.5K
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.2K
Synthesis and Characterization of Functionalized Metal-organic Frameworks
11:27

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

48.4K

Area of Science:

  • Crystallography
  • Materials Science
  • Medicinal Chemistry

Background:

  • Olmesartan is a widely prescribed angiotensin II receptor blocker.
  • Understanding solvate formation is crucial for drug stability and bioavailability.
  • Previous research has explored various crystalline forms of olmesartan.

Purpose of the Study:

  • To synthesize and characterize seven novel solvates of olmesartan.
  • To elucidate the crystal structures and intermolecular interactions within these solvates.
  • To investigate the influence of solvent molecules on the solid-state properties of olmesartan.

Main Methods:

  • Single-crystal X-ray diffraction for crystal structure determination.
  • Powder X-ray diffraction for bulk sample analysis.
  • Computational methods for lattice and binding energy calculations.
  • Hirshfeld and fingerprint plot analysis for intermolecular interactions.

Main Results:

  • Seven distinct solvates of olmesartan with methanol, ethanol, isopropanol, isobutanol, 2-ethoxyethanol, chloroform, and acetonitrile were successfully obtained.
  • Crystal structures revealed a 1:1 stoichiometry of olmesartan to solvent in the asymmetric unit for all solvates.
  • Analysis highlighted the role of hydrogen bonding and other intermolecular forces in stabilizing the crystal structures.
  • Lattice and binding energies were calculated, providing quantitative insights into solute-solvent interactions.

Conclusions:

  • The study successfully synthesized and characterized seven novel olmesartan solvates.
  • Detailed structural analysis provides a foundation for understanding olmesartan's solid-state behavior.
  • The findings contribute to the knowledge of solvate formation and crystal engineering for pharmaceutical applications.