Structural studies of various olmesartan solvates

Seven solvates of the angiotensin II receptor blocker agent olmesartan (C₂₄H₂₆N₆O₃), namely, the methanol (C₂₄H₂₆N₆O₃·CH₄O), ethanol (C₂₄H₂₆N₆O₃·C₂H₆O), isopropanol (C₂₄H₂₆N₆O₃·C₃H₈O), isobutanol (C₂₄H₂₆N₆O₃·C₄H₁₀O), 2-ethoxyethanol (C₂₄H₂₆N₆O₃·C₄H₁₀O₂), chloroform (C₂₄H₂₆N₆O₃·CHCl₃) and acetonitrile (C₂₄H₂₆N₆O₃·C₂H₃N) solvates, were successfully obtained. The crystal structures were determined using the single-crystal X-ray diffraction technique and the structural features are described, each solvate containing one molecule of olmesartan and one of solvent in the asymmetric unit. The samples were also analyzed by powder X-ray diffraction. Total lattice energies and binding energies between the olmesartan and solvent molecules were evaluated, which can be partitioned into electrostatic, polarization, dispersion and repulsion components. Hirshfeld and fingerprint plot analysis was performed to highlight the intermolecular contacts. Hydrogen bonding and supramolecular arrangements were comparatively studied for the seven solvates.