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Related Concept Videos

Microbial Classification System01:24

Microbial Classification System

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Classification is the process of organizing organisms into hierarchically inclusive groups based on their phenotypic similarities or evolutionary relationships. A species comprises one or more strains, and closely related species are grouped into genera. Genera are further classified into families, families into orders, orders into classes, and so forth, up to the domain level, which is the broadest taxonomic rank derived from a combination of phenotypic and genotypic data.The nomenclature of...
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Development of Antibiotic Resistance01:30

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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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Antibiotic Selection00:57

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Updated: Sep 28, 2025

The Use of a &#946;-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
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Consensus on β-Lactamase Nomenclature.

Patricia A Bradford1, Robert A Bonomo2, Karen Bush3

  • 1Antimicrobial Development Specialists LLC, Nyack, New York, USA.

Antimicrobial Agents and Chemotherapy
|April 5, 2022
PubMed
Summary
This summary is machine-generated.

Naming novel beta-lactamase (β-lactamase) genes has become inconsistent due to rapid growth. An international expert consensus meeting established a formal process for naming these important antibiotic resistance genes.

Keywords:
beta-lactamases

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Area of Science:

  • Microbiology
  • Genetics
  • Bioinformatics

Background:

  • Inconsistent naming of beta-lactamase (β-lactamase) variants causes confusion in scientific literature.
  • Whole genome sequencing has led to a rapid increase in identified β-lactamase genes.

Purpose of the Study:

  • To establish a standardized nomenclature for naturally occurring β-lactamase genes.
  • To formalize the process for naming novel β-lactamases.

Main Methods:

  • An international virtual meeting of β-lactamase experts was convened in November 2021.
  • A consensus was developed for naming novel β-lactamase genes.

Main Results:

  • A formal process for naming novel β-lactamases has been established.
  • This process facilitates consistent and clear communication in research.

Conclusions:

  • The newly formalized naming convention will reduce ambiguity in the literature.
  • Standardized naming is crucial for tracking and understanding antibiotic resistance evolution.