Consensus on β-Lactamase Nomenclature

Area of Science:

• Microbiology
• Genetics
• Bioinformatics

Background:

• Inconsistent naming of beta-lactamase (β-lactamase) variants causes confusion in scientific literature.
• Whole genome sequencing has led to a rapid increase in identified β-lactamase genes.

Purpose of the Study:

• To establish a standardized nomenclature for naturally occurring β-lactamase genes.
• To formalize the process for naming novel β-lactamases.

Main Methods:

• An international virtual meeting of β-lactamase experts was convened in November 2021.
• A consensus was developed for naming novel β-lactamase genes.

Main Results:

• A formal process for naming novel β-lactamases has been established.
• This process facilitates consistent and clear communication in research.

Conclusions:

• The newly formalized naming convention will reduce ambiguity in the literature.
• Standardized naming is crucial for tracking and understanding antibiotic resistance evolution.