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SWAN pathway-network identification of common aneuploidy-based oncogenic drivers.

Robert R Bowers1, Christian M Jones1, Edwin A Paz2

  • 1Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.

Nucleic Acids Research
|April 5, 2022
PubMed
Summary

Shifted Weighted Annotation Network (SWAN) analysis identifies cancer drivers by assessing cumulative monoallelic gene changes. This approach prioritizes oncogenes and tumor suppressors, revealing new therapeutic targets in solid tumors.

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