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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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Related Experiment Video

Updated: Sep 28, 2025

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health
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Brain aging by gut AGE.

Leslie K Ferrarelli1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|April 5, 2022
PubMed
Summary

Advanced glycation end products (AGEs) connect gut microbiome changes, a "leaky gut," and the aging of brain immune cells called microglia. This research highlights a novel pathway influencing brain health.

Area of Science:

  • Neuroscience
  • Microbiology
  • Aging Research

Background:

  • The gut microbiome plays a crucial role in overall health.
  • Microglia, the brain's immune cells, are implicated in aging and neurodegenerative diseases.
  • Advanced glycation end products (AGEs) are linked to aging and various pathologies.

Purpose of the Study:

  • To investigate the link between the gut microbiome, gut barrier integrity, and microglial aging.
  • To explore the role of advanced glycation end products (AGEs) in this pathway.

Main Methods:

  • Analysis of gut microbiome composition.
  • Assessment of gut permeability markers.
  • Evaluation of microglial activation and aging markers in preclinical models.

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Main Results:

  • Alterations in the gut microbiome composition were observed.
  • Increased gut permeability ("leaky gut") correlated with specific microbial profiles.
  • Elevated levels of AGEs were found in conjunction with microglial aging phenotypes.

Conclusions:

  • The gut microbiome, gut barrier function, and AGEs are interconnected.
  • This triad influences the aging process of microglia.
  • Findings suggest potential therapeutic targets for age-related neurological conditions by modulating the gut microbiome and AGEs.