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Advances in nanoparticle mediated targeting of RNA binding protein for cancer
Rama Kashikar1, Arun K Kotha1, Saurabh Shah2
1Department of Pharmaceutical Sciences, Mercer University College of Pharmacy, Atlanta, GA, USA.
Abstract:
RNA binding proteins (RBPs) enact a very crucial part in the RNA directive processes. Atypical expression of these RBPs affects many steps of RNA metabolism, majorly altering its expression. Altered expression and dysfunction of RNA binding proteins lead to cancer progression and other diseases. We enumerate various available interventions, and recent findings focused on targeting RBPs for cancer therapy and diagnosis. The treatment, sensitization, chemoprevention, gene-mediated, and virus mediated interventions were studied to treat and diagnose cancer. The application of passively and actively targeted lipidic nanoparticles, polymeric nanoparticles, virus-based particles, and vaccine-based immunotherapy for the delivery of therapeutic agent/s against cancer are discussed. We also discuss the formulation aspect of nanoparticles for achieving delivery at the site of action and ongoing clinical trials targeting RBPs.
Insights
Targeting RNA binding proteins (RBPs) offers new avenues for cancer therapy and diagnosis. Research explores various interventions, including nanoparticle-based drug delivery and immunotherapy, to combat cancer progression.
Area of Science:
- Molecular Biology
- Oncology
- Biotechnology
Background:
- RNA binding proteins (RBPs) play critical roles in RNA metabolism.
- Dysregulation of RBPs is implicated in cancer progression and other diseases.
Purpose of the Study:
- To review current interventions and recent findings in targeting RBPs for cancer therapy and diagnosis.
- To discuss the application of various delivery systems for therapeutic agents targeting RBPs.
Main Methods:
- Literature review of available interventions and recent findings.
- Discussion of nanoparticle-based delivery systems (lipidic, polymeric, virus-based) and immunotherapy.
- Exploration of formulation aspects for targeted delivery and clinical trials.
Main Results:
- Various interventions including gene-mediated and virus-mediated therapies are being explored.
- Nanoparticle formulations and immunotherapy show promise for targeted cancer treatment.
- Ongoing clinical trials are investigating RBP-targeting strategies.
Conclusions:
- Targeting RBPs presents a promising strategy for novel cancer diagnostics and therapeutics.
- Advanced delivery systems are crucial for effective RBP-targeted cancer interventions.
- Further research and clinical trials are essential to realize the full potential of RBP-targeted therapies.
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