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Related Experiment Video

Updated: Sep 28, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Pregnancy in systemic sclerosis.

Mauro Betelli1, Silvia Breda2, Veronique Ramoni3

  • 1Internal Medicine, Bolognini Hospital, Bergamo - Italy.

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|April 6, 2022
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Pregnancy in systemic sclerosis is generally stable, though prematurity is higher. Women with pulmonary hypertension face high maternal mortality risks and should avoid pregnancy.

Keywords:
PregnancyPrematurityRenal crisisSclerodermaSystemic sclerosis

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Area of Science:

  • Rheumatology and Obstetrics
  • Systemic Sclerosis (SSc) and Pregnancy Outcomes

Background:

  • Systemic sclerosis (SSc) is a chronic autoimmune disease affecting connective tissues.
  • Pregnancy in women with SSc requires careful management due to potential complications.

Purpose of the Study:

  • To review current literature on pregnancy in systemic sclerosis.
  • To provide guidance for physicians on critical management issues for SSc patients during pregnancy.

Main Methods:

  • Comprehensive review of retrospective and prospective studies.
  • Analysis of fertility, pregnancy loss, prematurity, and maternal/fetal outcomes in SSc.
  • Evaluation of disease stability and specific risk factors like pulmonary hypertension.

Main Results:

  • Fertility is typically normal; spontaneous loss rates are comparable to the general population.
  • Prematurity is elevated in SSc pregnancies, similar to other rheumatic diseases.
  • Placental vasculopathy is observed in some cases; disease often remains stable during pregnancy.

Conclusions:

  • Women with SSc and pulmonary hypertension should avoid pregnancy due to high mortality risk.
  • Management requires pre-conception planning, organ involvement assessment, and teratogenic drug avoidance.
  • High-risk pregnancy teams are crucial for optimal maternal and neonatal outcomes.