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Raynaud's phenomenon.

Ariane L Herrick1,2

  • 1Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

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|April 6, 2022
PubMed
Summary
This summary is machine-generated.

Raynaud's phenomenon, particularly when linked to systemic sclerosis, can severely impact quality of life and lead to digital ulcers. This review focuses on recent advances in understanding and treating this challenging condition.

Keywords:
Raynaud’s phenomenonSystemic sclerosisassessmentdiagnosismanagement

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Area of Science:

  • Rheumatology
  • Vascular Medicine

Background:

  • Raynaud's phenomenon is categorized as primary (idiopathic) or secondary to conditions like systemic sclerosis.
  • Primary Raynaud's affects 3-5% of the population, while the systemic sclerosis-related form can be severe, causing digital ulcers in 50% of patients.
  • Raynaud's phenomenon significantly impairs patients' quality of life.

Purpose of the Study:

  • To review recent advances in the research and treatment of systemic sclerosis-related Raynaud's phenomenon.
  • To discuss epidemiology, pathogenesis, diagnosis, and assessment of Raynaud's phenomenon.
  • To cover treatment strategies for both uncomplicated and complicated Raynaud's phenomena, including digital ulceration and critical ischemia.

Main Methods:

  • Literature review focusing on systemic sclerosis-related Raynaud's phenomenon.
  • Analysis of epidemiological data, including the transition from isolated to systemic sclerosis-related forms.
  • Synthesis of current knowledge on pathogenesis, diagnosis, assessment, and treatment.

Main Results:

  • Systemic sclerosis-related Raynaud's phenomenon is a significant clinical challenge with a high risk of digital ulceration.
  • Recent research has provided insights into the epidemiology, pathogenesis, and management of this condition.
  • Effective treatment strategies exist for both uncomplicated and complicated Raynaud's phenomena.

Conclusions:

  • Systemic sclerosis-related Raynaud's phenomenon requires specialized attention due to its severity and potential for complications.
  • Continued research is crucial to address the remaining challenges in managing this condition over the next 5-10 years.
  • A comprehensive understanding of epidemiology, pathogenesis, and treatment is essential for improving patient outcomes.