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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
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COVID-19 in patients with systemic lupus erythematosus: A systematic review

Xue-Lei Fu1, Yan Qian2, Xiao-Hong Jin2

  • 1School of Medicine, 66479Nantong University, Nantong, Jiangsu, China.

Lupus
|April 6, 2022
PubMed

Insights

Systemic lupus erythematosus (SLE) patients with COVID-19 experienced challenges in healthcare access and psychological distress. Hydroxychloroquine did not prevent COVID-19 in these patients.

Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Epidemiology

Background:

  • Systemic lupus erythematosus (SLE) is an autoimmune disease.
  • Coronavirus disease 2019 (COVID-19) is a global pandemic.
  • Understanding the intersection of SLE and COVID-19 is crucial for patient care.

Purpose of the Study:

  • To review the epidemiology of SLE and COVID-19.
  • To identify clinical characteristics and treatment of COVID-19 in SLE patients.
  • To assess the pandemic's impact on SLE patients' health and healthcare access.

Main Methods:

  • Systematic literature review of PubMed.
  • Inclusion criteria: human studies on COVID-19 in SLE patients, published Dec 2019-June 2021.
  • 52 studies were included in the review.

Main Results:

  • COVID-19 prevalence in SLE patients ranged from 0.0% to 18.1%; hospitalization rates were 0.24% to 10.6%.
  • COVID-19 infection can mimic SLE flares.
  • Hydroxychloroquine was ineffective for COVID-19 prevention; patients faced healthcare access issues, financial strain, and psychological distress.

Conclusions:

  • The COVID-19 pandemic significantly impacted SLE patients' mental and physical health.
  • Adequate healthcare access, containment policies, and psychological support are essential for managing SLE patients during pandemics.
  • COVID-19 management in SLE requires careful consideration of disease-specific factors and patient well-being.

Keywords:
COVID-19SARS-CoV-2SLESystematic Review

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