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Therapeutic Drug Monitoring as a Tool for Therapy Optimization.
Merin Babu1, Keechilat Pavithran1
1Department of Medical Oncology, Amrita Institute of Medical Sciences and Research Centre Amrita Vishwa Vidyapeetham, Ponekkara P.O, Kochi, Kerala, India.
Drug Metabolism Letters
|April 6, 2022
Summary
Pharmacotherapy requires careful monitoring to avoid ineffective or toxic drug levels. Therapeutic drug monitoring, using pharmacokinetic and pharmacodynamic methods, enables individualized treatment for chronic conditions.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Pharmacometrics
Background:
- Increasing use of pharmacotherapy necessitates improved patient outcomes.
- Suboptimal drug dosing leads to either subtherapeutic treatment or adverse drug reactions.
- Chronic conditions like epilepsy, cardiovascular diseases, and oncological, neurological, and psychiatric disorders require routine drug monitoring.
Purpose of the Study:
- To explore the role and potential developments of therapeutic drug monitoring (TDM) in India.
- To highlight the shift from fixed-dosing to individualized treatment strategies.
- To discuss the application of pharmacokinetic, pharmacodynamic, and pharmacometric methods in TDM.
Main Methods:
- Review of global experiences and practices in therapeutic drug monitoring.
- Analysis of pharmacokinetic, pharmacodynamic, and pharmacometric approaches.
- Exploration of targeted therapies and individualized treatment.
Main Results:
- Current pharmacotherapy practices often result in sub-optimal patient outcomes due to dosing issues.
- Therapeutic drug monitoring offers a pathway to optimize drug efficacy and safety.
- Individualized treatment, guided by TDM, is emerging as a superior approach.
Conclusions:
- Therapeutic drug monitoring is crucial for managing chronic conditions effectively.
- The global experience with TDM provides a foundation for its development in India.
- Pharmacokinetic, pharmacodynamic, and pharmacometric methods are essential tools for advancing TDM.
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