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miR-638: A Promising Cancer Biomarker with Therapeutic Potential
Elham Hasheminasabgorji1,2, Mohammad Amir Mishan3, Mohammad Amin Khazeei Tabari4,5
1Department of Clinical Biochemistry and Medical Genetics, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Background:
There is an unmet need to improve the diagnosis of cancer with precise treatment strategies. Therefore, more powerful diagnostic, prognostic, and therapeutic biomarkers are needed to overcome tumor cells. microRNAs (miRNAs, miRs), as a class of small non-coding RNAs, play essential roles in cancer through the tumor-suppressive or oncogenic effects by post-transcriptional regulation of their targets. Many studies have provided shreds of evidence on aberrantly expressed miRNAs in numerous cancers and have shown that miRNAs could play potential roles as diagnostic, prognostic, and even therapeutic biomarkers in patients with cancers. Findings have revealed that miR-638 over or underexpression might play a critical role in cancer initiation, development, and progression. However, the mechanistic effects of miR-638 on cancer cells are still controversial.
Conclusion:
In the present review, we have focused on the diagnostic, prognostic, and therapeutic potentials of miR-638 and discussed its mechanistic roles in various types of cancers.
Insights
MicroRNAs (miRNAs) are crucial in cancer development. This review explores miR-638
Area of Science:
- Oncology
- Molecular Biology
- Biomarker Discovery
Background:
- Cancer diagnosis and treatment require improved biomarkers.
- MicroRNAs (miRNAs) regulate gene expression and are implicated in cancer.
- Aberrant miRNA expression is observed across various cancers, suggesting diagnostic and prognostic potential.
Approach:
- This review synthesizes current research on miR-638.
- It focuses on the diagnostic, prognostic, and therapeutic roles of miR-638.
- Mechanistic insights into miR-638's function in cancer cells are discussed.
Key Points:
- miR-638 exhibits altered expression in numerous cancers.
- Overexpression or underexpression of miR-638 is linked to cancer initiation, progression, and development.
- miR-638 shows potential as a diagnostic, prognostic, and therapeutic biomarker.
Conclusions:
- miR-638 holds significant potential as a biomarker in oncology.
- Further research is needed to clarify the controversial mechanistic roles of miR-638 in cancer.
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