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Unusual Presentation of Helicobacter pylori Infection as PSMA-Avid Gastric Mass
Ritesh Ramesh Suthar1, Archi Agrawal, Kedar Deodhar
1From the Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India.
Abstract:
68 Ga-PSMA PET/CT is one of the most common imaging uses for prostate cancer imaging. Although initially thought to be specific for prostate cancer, there are many evidences that are coming of its concentration in many other neoplastic and nonneoplastic pathologies. Helicobacter pylori is the most common bacteria causing gastric inflammation and usually presents with gastroduodenal ulcer. Here we present one unusual case of benign gastric mass formation caused by H. pylori infection with PSMA concentration.
Insights
Gallium-68 PSMA PET/CT, commonly used for prostate cancer, can concentrate in benign conditions. This case highlights a rare benign gastric mass caused by Helicobacter pylori infection showing PSMA uptake.
Area of Science:
- Nuclear Medicine
- Oncology
- Gastroenterology
Background:
- 68Ga-PSMA PET/CT is a standard imaging modality for prostate cancer.
- PSMA expression is not exclusive to prostate cancer, appearing in other pathologies.
- Helicobacter pylori infection commonly causes gastric inflammation and ulcers.
Observation:
- A patient presented with a benign gastric mass.
- The mass demonstrated significant uptake on 68Ga-PSMA PET/CT.
- Helicobacter pylori infection was identified as the cause of the gastric mass.
Findings:
- This case demonstrates an unusual instance of benign gastric mass formation.
- The gastric mass was attributed to Helicobacter pylori infection.
- The mass exhibited PSMA avidity, mimicking neoplastic lesions.
Implications:
- 68Ga-PSMA PET/CT findings in the stomach require careful interpretation.
- PSMA uptake can occur in non-neoplastic, infectious conditions like H. pylori.
- This highlights the importance of considering differential diagnoses for gastric PSMA uptake.
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