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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Benzimidazole hybrids as anticancer drugs: An updated review on anticancer properties, structure-activity

Lian-Shun Feng1, Wen-Qi Su1, Jin-Bo Cheng1

  • 1WuXi AppTec Co., Ltd., Wuhan, People's Republic of China.

Archiv Der Pharmazie
|April 6, 2022
PubMed

Insights

Benzimidazole hybrids show promise as novel anticancer agents, offering diverse mechanisms to combat drug resistance and cancer growth. This review highlights their potential for developing new cancer therapies.

Area of Science:

  • Medicinal Chemistry
  • Oncology
  • Drug Discovery

Background:

  • Cancer is a leading global cause of death, driven by cell cycle deregulation and uncontrolled growth.
  • Existing anticancer drugs often face multidrug resistance, necessitating novel therapeutic strategies.
  • Benzimidazole derivatives exhibit anticancer properties via multiple mechanisms, including apoptosis induction and cell cycle arrest.

Purpose of the Study:

  • To provide a comprehensive overview of benzimidazole hybrids as potential anticancer agents.
  • To discuss structure-activity relationships and mechanisms of action for rational drug design.
  • To cover relevant research published between 2019 and 2021.

Main Methods:

  • Literature review of scientific articles.
  • Analysis of structure-activity relationships (SAR) of benzimidazole hybrids.
  • Examination of proposed mechanisms of action against cancer cells.

Main Results:

  • Benzimidazole derivatives demonstrate significant anticancer potential through various pathways.
  • Benzimidazole hybrids can exhibit dual or multiple antiproliferative activities.
  • These hybrids show promise in overcoming multidrug resistance in cancer treatment.

Conclusions:

  • Benzimidazole hybrids represent a valuable scaffold for developing next-generation anticancer drugs.
  • Understanding SAR and mechanisms is crucial for designing more effective benzimidazole-based cancer therapeutics.
  • Benzimidazole hybrids hold potential for clinical application in cancer control and eradication.
Keywords:
anticancerbenzimidazolehybrid moleculesmechanisms of actionstructure-activity relationship

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