Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

4.1K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.1K
Fractures: Bone Repair01:27

Fractures: Bone Repair

3.8K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.8K
Bone Remodeling01:40

Bone Remodeling

38.6K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.6K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.3K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.3K
Compact Bone01:27

Compact Bone

13.3K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
13.3K
Spongy Bone01:09

Spongy Bone

5.7K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modified in-line Sagnac interferometer with passive demodulation technique for environmental immunity of a fiber-optic current sensor.

Applied optics·2008
Same author

Education and imaging. Gastrointestinal: bleeding gastric diverticulum.

Journal of gastroenterology and hepatology·2008
Same author

Simple high-coherence rapidly tunable external-cavity diode laser.

Optics letters·2007
Same author

BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor.

Oncogene·2007
Same author

Prostacyclin protects renal tubular cells from gentamicin-induced apoptosis via a PPARalpha-dependent pathway.

Kidney international·2007
Same author

Serum cardiac troponin response in adolescents playing basketball.

International journal of sports medicine·2007

Related Experiment Video

Updated: Sep 27, 2025

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

2.8K

[Bone damage in osteoporotic fractures].

H Lin1, Lihua Bao2

  • 1the Center of Research for Metabolic Bone Disease, the Department of Orthopedics, the Affiliated Drum Tower Hospital of Medical School, Nanjing University, Nanjing 210008, China.

Zhonghua Yi Xue Za Zhi
|April 7, 2022
PubMed
Summary

Osteoporotic fractures differ from traumatic ones, stemming from weakened bone strength due to osteoporosis. Addressing bone lesions and risks through anti-osteoporosis treatment is crucial for effective fracture intervention and preventing re-fractures.

More Related Videos

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.3K
Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
09:02

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

700

Related Experiment Videos

Last Updated: Sep 27, 2025

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

2.8K
Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.3K
Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
09:02

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

700

Area of Science:

  • Orthopedics
  • Gerontology
  • Pathology

Background:

  • Osteoporotic fractures are pathological, distinct from traumatic fractures, characterized by reduced bone strength.
  • Bone strength depends on material properties, tissue structure, and muscle load, all affected in osteoporosis.
  • Pathological changes in osteoporotic fractures involve loss of bone mass and deterioration of bone quality.

Purpose of the Study:

  • To elaborate on the material properties and tissue structure damage in osteoporotic fractures.
  • To emphasize the importance of recognizing and managing these specific bone lesions and their associated risks.
  • To highlight the critical role of anti-osteoporosis treatment in managing osteoporotic fractures.

Main Methods:

  • Literature review and analysis of bone material properties.
  • Examination of bone tissue structure alterations in osteoporosis.
  • Discussion of clinical implications for fracture intervention and management.

Main Results:

  • Osteoporotic fractures result from compromised bone strength due to decreased bone mass and quality.
  • Surgical intervention alone does not prevent further bone damage progression in osteoporotic fractures.
  • Understanding material and structural bone damage is key to managing osteoporotic fractures.

Conclusions:

  • Anti-osteoporosis treatment is essential for improving clinical outcomes in osteoporotic fractures.
  • Early identification and management of bone lesions are vital for fracture intervention.
  • Addressing bone quality and strength is paramount in preventing recurrent fractures in osteoporotic patients.