Absolute band neutrophils count is a predictor of overall survival in advanced uterine cervical cancer

Neutrophils play a role during the oncogenic process, and their count can be a prognostic marker. The objective was to evaluate the association of band and segmented neutrophils with prognostic factors, overall survival, and disease-free survival in advanced uterine cervical cancer (IIB to IVB staging).

This study evaluated 88 patients diagnosed with uterine cervical cancer staging IIB to IVB. The recorded data from medical records were age, parity, staging, histological type, absolute count of total neutrophils, band neutrophils and segmented neutrophils, disease-free survival, and overall survival. Receiver-operating characteristic (ROC) curve was used to obtain the area under the curve (AUC) and determine the best cut-off values for each parameter. Survival was verified by the Kaplan-Meier method, and multivariate analysis was performed by Cox regression. The level of significance was ≤ 0.05.

Regarding the total neutrophils, band, and segmented neutrophils count, a cut-off value of 6187/mm³, 273 mm³ and 6062/mm³ were found, respectively. Overall survival was shorter in patients with total neutrophils greater than 6187/mm³ (p = 0.012), band neutrophils greater than 273/mm³ (p = 0.001), and segmented neutrophils greater than 6062/mm³ (p = 0.013). After multivariate analysis considering the two types of neutrophils, only band neutrophils greater than 273/mm³ remained as an independent factor for shorter overall survival.

The absolute count of band neutrophils greater than 273/mm³ was a potential predictor of shorter overall survival in women with invasive cervical cancer. This count can be of great clinical use, in addition to being inexpensive, less invasive, and easy to perform.