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Updated: Sep 27, 2025

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Role of High Mobility Group Box 1 in Cardiovascular Diseases

Souad Belmadani1, Khalid Matrougui2

  • 1Department of Physiological Sciences, EVMS, Norfolk, Virginia, 23501, USA.

Inflammation
|April 7, 2022
PubMed

Insights

High Mobility Group Box 1 (HMGB1) protein, crucial in inflammation, is increasingly linked to cardiovascular diseases. Understanding HMGB1

Area of Science:

  • Molecular Biology
  • Immunology
  • Cardiology

Background:

  • High Mobility Group Box 1 (HMGB1) is a conserved protein with nuclear, cytosolic, and extracellular functions.
  • HMGB1's role in inflammation is established, but its specific involvement in cardiovascular diseases requires further elucidation.
  • Cellular localization and posttranslational modifications influence HMGB1's diverse biological activities.

Purpose of the Study:

  • To review recent findings on the pathophysiological connection between HMGB1 and cardiovascular complications.
  • To emphasize the role of inflammation in HMGB1-mediated cardiovascular effects.
  • To explore the potential of HMGB1-based therapeutic strategies for cardiovascular diseases.

Main Methods:

  • Literature review of recent scientific reports and studies.
  • Analysis of existing data on HMGB1's function in cellular signaling and secretion.
  • Focus on studies linking HMGB1 to inflammatory processes in the cardiovascular system.

Main Results:

  • HMGB1 translocates from the nucleus to the cytoplasm and is secreted extracellularly.
  • Evidence suggests a significant role for HMGB1 in the inflammatory pathways underlying cardiovascular complications.
  • The precise mechanisms of HMGB1's involvement in cardiovascular disease pathogenesis are under active investigation.

Conclusions:

  • HMGB1 is implicated in the development and progression of cardiovascular diseases through inflammatory mechanisms.
  • Further research into HMGB1's function is crucial for understanding cardiovascular pathology.
  • Targeting HMGB1 may offer novel therapeutic avenues for treating cardiovascular conditions.

Keywords:
HMGB1angiogenesis.cardiovasculardiabetesinflammation

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