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Microcarriers in application for cartilage tissue engineering: Recent progress and challenges.

Sheng-Long Ding1, Xin Liu2, Xi-Yuan Zhao2

  • 1Center of Foot and Ankle Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.

Bioactive Materials
|April 7, 2022
PubMed
Summary
This summary is machine-generated.

Microcarriers (MCs) are crucial for cartilage tissue engineering (TE), offering advanced cell regulation and injectable delivery for regeneration. This review details MC fabrication, materials, applications, and design principles for future medical use.

Keywords:
BioprintingCargo deliveryCartilage regenerationCartilage tissue engineeringMicrocarriers

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Cartilage tissue regeneration at a clinical scale remains a significant challenge.
  • Microcarriers (MCs) are widely explored in various medical fields, particularly for cartilage tissue engineering (TE).
  • MCs offer methods for regulating cell phenotype, microtissue maturation, and serve as injectable carriers.

Purpose of the Study:

  • To review fabrication methods and materials for diverse microcarrier types.
  • To highlight recent advancements in microcarrier applications for cartilage regeneration.
  • To summarize challenges and future prospects of microcarrier-based systems in medical applications.

Main Methods:

  • Review of typical microcarrier fabrication techniques.
  • Discussion of suitable materials for microcarrier development.
  • Analysis of recent applications and design principles for microcarriers in TE.

Main Results:

  • Microcarrier systems show promise in regulating cell behavior and enhancing cartilage regeneration.
  • Various fabrication methods and materials are available for MCs, influencing their performance.
  • Recent progress indicates significant potential for MCs in clinical applications.

Conclusions:

  • Microcarriers offer a versatile platform for cartilage tissue engineering.
  • Rational design and application of MCs require careful consideration of materials and fabrication.
  • This review provides guidelines for developing effective microcarrier-based strategies for cartilage TE.