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Rare Cases of Filarial Chyluria in Children
Shetanshu Srivastava1, Vandana Tiwari2, Manodeep Sen3
1Department of Pediatrics, Dr. Ram Manohar Lohia Institute of Medical Sciences Lucknow, Lucknow, UP, India.
Insights
Lymphatic filariasis (LF) presenting as white urine is rare in children. Early diagnosis and management are crucial for favorable outcomes in pediatric cases of this parasitic infection.
Area of Science:
- Pediatric infectious diseases
- Parasitology
- Urology
Background:
- Lymphatic filariasis (LF) is a parasitic disease with a long incubation period (5-20 years), making it uncommon in children.
- Abnormal lymphatic-urinary communication, a rare manifestation of LF, can lead to the passage of milky white urine (chyluria).
- High index of suspicion is necessary for diagnosing pediatric LF due to subtle initial symptoms, unlike adult manifestations like lymphedema or hydrocele.
Observation:
- This report details two pediatric cases experiencing intermittent chyluria for one year.
- Diagnostic workup revealed elevated urine triglycerides and positive filarial antigen tests in both patients.
- The study highlights the utility of point-of-care diagnostic tests for LF in children.
Findings:
- Confirmed diagnosis of lymphatic filariasis in pediatric patients presenting with chyluria.
- Successful symptom remission achieved through medical management.
- Demonstrated the effectiveness of rapid diagnostic methods in identifying LF.
Implications:
- Emphasizes the importance of considering LF in pediatric patients with chyluria.
- Highlights the need for increased awareness and early detection of LF in children.
- Suggests that prompt medical intervention can lead to positive patient outcomes.
Background:
Lymphatic filariasis leading to the passage of white urine or chyle is a rare manifestation in children. Filarial parasite infiltration leading to abnormal lymphatic-urinary communication occurs with prolonged infection. The incubation period ranges from 5 to 20 yrs., thus relatively infrequent in the pediatric age group. Index of suspicion should be high when a child presents with the passage of white urine because the subclinical manifestation of filarial infection is difficult to recognize. Moreover, more pathognomonic clinical manifestations such as lymphoedema or hydrocoele are present in adulthood. It should also be differentiated from non-parasitic causes like nephrotic syndrome, urates and phosphates in urine, and congenital lymphatic-urinary communication.
Case Presentation:
We report two pediatric cases with the intermittent passage of milky white urine since one year. Institutional ethical committee approved the study. In both patients, urine triglycerides were high, and the presence of positive filarial antigen test confirmed the diagnosis. Medical management showed remission of symptoms. Our cases highlight the rare presentation of LF in children and the use of point of care diagnostic tests, management, and outcome in them.
Conclusion:
LF is a rare condition in children, and the index of suspicion should be high for early management.
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