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Updated: Sep 27, 2025

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
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The COMPARE Database: A Public Resource for Allergen Identification, Adapted for Continuous Improvement.

Ronald van Ree1, Dexter Sapiter Ballerda2, M Cecilia Berin3

  • 1Departments of Experimental Immunology and of Otorhinolaryngology, Amsterdam University Medical Centers, Amsterdam, Netherlands.

Frontiers in Allergy
|April 7, 2022
PubMed
Summary

A new database, the Comprehensive Protein Allergen Resource (COMPARE), identifies allergenic proteins using advanced bioinformatics. This resource aids in assessing food safety and public health by providing transparent, consensus-based data.

Keywords:
GMOallergen databaseallergenicity assessmentbioinformaticsrisk assessmentsequence comparison

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Area of Science:

  • Food Science and Technology
  • Bioinformatics
  • Toxicology

Background:

  • Assessing allergenicity of proteins is crucial for food safety, especially with genetically modified foods.
  • Increasing genomic data complicates the identification of potential new allergens.
  • Existing methods require a transparent, consensus-based approach for reliable safety reviews.

Purpose of the Study:

  • To develop a comprehensive, adaptable, high-throughput process for identifying allergenic protein sequences.
  • To create the Comprehensive Protein Allergen Resource (COMPARE) database and associated bioinformatics tools.
  • To ensure the resource aligns with Food and Agriculture Organization/World Health Organization (FAO/WHO) and Codex Alimentarius Commission guidelines.

Main Methods:

  • Automated keyword-based sorting algorithms and manual curation of protein sequence entries.
  • Yearly literature database searches to identify novel allergen sequences.
  • Development of sequence comparison tools for evaluating protein allergenicity.

Main Results:

  • Established the publicly accessible COMPARE database with bioinformatics tools.
  • Implemented a transparent, continuously improving process for allergen identification.
  • Included peer-review comments to enhance decision-making transparency.

Conclusions:

  • The COMPARE database provides a vital resource for food safety assessments.
  • The developed process offers a high-throughput, adaptable method for allergen identification.
  • This initiative supports international guidelines for food and feed safety reviews.