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Pharmacological Rationale for Targeting IL-17 in Asthma
Siti Farah Rahmawati1,2,3, Maurice Te Velde1,3, Huib A M Kerstjens3,4
1Department of Molecular Pharmacology, University of Groningen, Groningen, Netherlands.
Frontiers in Allergy
|April 7, 2022
Summary
Interleukin 17 (IL-17) is linked to severe asthma and reduced response to treatments. Targeting the IL-17 pathway may offer new therapeutic options for difficult-to-treat asthma patients.
Area of Science:
- Immunology
- Respiratory Medicine
- Pharmacology
Background:
- Asthma affects 300 million globally, characterized by airway inflammation and obstruction.
- Elevated Interleukin 17 (IL-17) levels correlate with asthma severity and reduced inhaled corticosteroid (ICS) sensitivity.
- Current biologics are effective for T helper 2 (Th2)-high asthma, but Th17-high asthma shows limited response.
Purpose of the Study:
- To review the role of IL-17 in asthma pathogenesis.
- To discuss the interaction between the IL-17 and Th2 pathways in asthma.
- To explore the therapeutic potential of targeting the IL-17 pathway in severe asthma.
Main Methods:
- Literature review of studies investigating IL-17 in asthma.
- Analysis of experimental models of asthma involving the IL-17 axis.
- Discussion of clinical data on Th17-high asthma and treatment responses.
Main Results:
- Increased IL-17 levels are a biomarker for severe asthma phenotypes.
- The Th17/IL-17 axis is implicated in reduced sensitivity to ICS.
- Targeting IL-17 may overcome ICS unresponsiveness and benefit specific asthma subpopulations.
Conclusions:
- The IL-17 pathway represents a promising therapeutic target for severe asthma.
- Understanding IL-17's role is crucial for developing novel treatments for non-responsive asthma.
- Targeting IL-17 could potentially reverse corticosteroid resistance in asthma.
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