Cardiovascular-specific mortality among multiple myeloma patients: a population-based study
Xuejiao Yin1, Fengjuan Fan2, Bo Zhang2
1Department of Hematology, The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou, China.
Therapeutic Advances in Hematology
|April 7, 2022
Summary
Cardiovascular disease mortality (CVM) is significantly higher in multiple myeloma (MM) patients compared to the general population. Focusing on cardiovascular health after MM diagnosis is crucial for improving patient survival rates.
Area of Science:
- Oncology
- Cardiology
- Epidemiology
Background:
- Multiple myeloma (MM) survival has improved, with patients often living longer.
- Cardiovascular health is a critical factor for long-term survival in MM patients.
- MM is typically diagnosed in older adults (median age 66-70).
Purpose of the Study:
- To investigate cardiovascular disease mortality (CVM) trends in MM patients.
- To compare CVM risks in MM patients versus the general population.
Main Methods:
- Analysis of 88,328 MM patients from the Surveillance, Epidemiology, and End Results (SEER) database (1975-2016).
- Utilized standardized mortality ratios (SMRs) to evaluate CVM risk.
Main Results:
- MM patients exhibited a significantly higher CVM risk (SMR 1.84) than the general population.
- The highest CVM risk in MM patients occurred within the first year post-diagnosis (SMR 2.62), decreasing over time.
- CVM was the second leading cause of death in MM patients aged 75+; incidence decreased in older age groups but not younger ones.
Conclusions:
- Cardiovascular disease mortality risk is substantially elevated in multiple myeloma patients.
- Prioritizing cardiovascular health assessment and management at the time of MM diagnosis is essential for enhancing patient outcomes and survival.
Keywords:
cardiovascular disease mortalitycompeting riskmultiple myelomaprognosisstandardized mortality ratiostrendsMore Related Videos
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