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Related Concept Videos

Aneurysm I: Introduction01:30

Aneurysm I: Introduction

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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

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Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
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Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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The Arch of Aorta01:10

The Arch of Aorta

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The coronary arteries, originating from the ascending aorta, bifurcate from two sinuses located within the ascending aorta. Positioned just above the aortic semilunar valve, these sinuses house essential aortic baroreceptors and chemoreceptors, crucial for maintaining cardiac function. The left coronary artery and the right coronary artery branch off from the left posterior and anterior aortic sinuses, respectively.
Encircling the heart, the coronary arteries form a ring-like structure before...
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The Aorta01:14

The Aorta

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The aorta is the largest artery in the human body. It originates from the left ventricle of the heart and extends down to the abdomen, where it splits into two smaller arteries. Structurally, it can be divided into four main parts: the ascending aorta, the aortic arch, the thoracic aorta, and the abdominal aorta.
The average diameter of the aorta is approximately 2-3 cm, but the size can vary depending on the section of the aorta and the individual's age, sex, and body size. The aorta is...
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Related Experiment Video

Updated: Sep 27, 2025

Modified Octopus Technique for Thoracoabdominal Aortic Aneurysm
04:56

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Published on: August 1, 2025

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Ascending aorta aneurysm in scleroderma.

Bhavya Chintala1, Lalit Duggal1, Neeraj Jain1

  • 1Department of Rheumatology and clinical Immunology, Sir Ganga Ram Hospital, New Delhi, India.

Journal of Scleroderma and Related Disorders
|April 7, 2022
PubMed
Summary
This summary is machine-generated.

Scleroderma, a connective tissue disease, can affect the aorta, leading to ascending aorta aneurysm. This case highlights a rare instance of this macrovascular complication in a patient with diffuse cutaneous scleroderma.

Keywords:
Ascending aortaaneurysmscleroderma

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Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Radiology

Background:

  • Scleroderma is a systemic autoimmune disease characterized by fibrosis and vascular abnormalities.
  • Macrovascular involvement, particularly ascending aorta aneurysm, is an under-recognized complication of scleroderma.
  • Diffuse cutaneous scleroderma presents with widespread skin thickening and potential organ involvement.

Observation:

  • A 56-year-old female with rapidly progressive diffuse cutaneous scleroderma presented with characteristic skin thickening, arthritis, Raynaud's phenomenon, dyspnea, chest discomfort, and dysphagia.
  • Laboratory investigations revealed positive antinuclear antibody and Scl 70.
  • Imaging demonstrated interstitial lung disease with a nonspecific interstitial pneumonia pattern and a 6.5 cm fusiform dilatation of the ascending aorta.

Findings:

  • The patient exhibited features consistent with systemic scleroderma, including interstitial lung disease.
  • A significant finding was the presence of a large ascending aorta aneurysm (6.5 cm), indicating macrovascular complication.
  • The case underscores the association between scleroderma and aortic dilatation.

Implications:

  • This case report contributes to the limited literature on ascending aorta aneurysms in scleroderma patients.
  • It emphasizes the importance of considering cardiovascular surveillance in scleroderma patients, especially those with diffuse cutaneous involvement.
  • Further research is needed to elucidate the pathogenesis and optimal management of aortic aneurysms in scleroderma.