ABCA7 rs3764650 Polymorphism is Associated with Delayed Neurocognitive Recovery

Area of Science:

• Genetics
• Neuroscience
• Geriatrics

Background:

• ATP-binding cassette transporter A7 (ABCA7) gene variations are implicated in cognitive impairment.
• Previous research suggests a link between ABCA7 gene variation and cognitive decline.

Purpose of the Study:

• To investigate the association between the ABCA7 rs3764650 polymorphism and perioperative neurocognitive disorder (pNCD).
• To explore the role of ABCA7 gene variants in postoperative cognitive dysfunction.

Main Methods:

• 132 elderly patients undergoing elective non-cardiac surgery and 28 healthy controls were enrolled.
• Neuropsychological tests were administered preoperatively and at 7 days and 3 months postoperatively.
• Genotyping of ABCA7 rs3764650 was performed using PCR and RFLP analysis.

Main Results:

• Incidences of delayed neurocognitive recovery (dNCR) and postoperative cognitive disorder (POCD) were 29.7% and 16.8%, respectively.
• Higher G allele and GG genotype frequencies were observed in patients with dNCR at 7 days post-surgery (P=0.035 and P=0.013).
• No significant association was found between ABCA7 alleles and POCD at 3 months post-surgery.

Conclusions:

• The ABCA7 rs3764650 polymorphism is associated with dNCR in elderly surgical patients.
• The GG genotype of ABCA7 rs3764650 may be a predisposing factor for postoperative cognitive impairment in Chinese Han elderly individuals.