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Related Experiment Video

Updated: Sep 27, 2025

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

Carbon Nanoparticles for Thyroidectomy and Central Lymph Node Dissection for Thyroid Cancer.

Rong-Jia Zhang¹, Yu-Lu Chen², Xian Deng¹

¹Department of Thyroid Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

The American Surgeon

|April 7, 2022

Summary

Carbon nanoparticles (CNs) improve lymph node dissection during thyroid cancer surgery. CNs aid in identifying more lymph nodes and reduce parathyroid gland complications, enhancing surgical outcomes.

Keywords:

carbon nanoparticles meta-analysis thyroidectomy

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Last Updated: Sep 27, 2025

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach

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Published on: September 15, 2023

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Area of Science:

Endocrinology
Surgical Oncology
Nanomedicine

Background:

Thyroid cancer (TC) necessitates meticulous surgical intervention, including total or near-total thyroidectomy and central lymph node dissection (CLND).
Optimizing lymph node yield and preserving parathyroid gland (PG) function are critical challenges in TC surgery.

Approach:

A systematic literature review and meta-analysis were conducted, examining randomized controlled trials and non-randomized controlled trials.
Data from 1870 patients were analyzed to compare outcomes with and without the use of carbon nanoparticles (CNs) during CLND.

Key Points:

CN application significantly increased the number of central lymph nodes and metastatic lymph nodes dissected.
The use of CNs was associated with a lower rate of accidental parathyroidectomy and reduced incidence of transient hypoparathyroidism and hypocalcemia.
No significant differences were observed in rates of permanent hypoparathyroidism, permanent hypocalcemia, or transient recurrent laryngeal nerve (RLN) paralysis.

Conclusions:

Carbon nanoparticles enhance the effectiveness of lymph node dissection in thyroid cancer surgery.
CNs demonstrate a protective effect on parathyroid glands and their function during thyroidectomy with CLND.
Further research may explore long-term functional outcomes and refine CN application techniques.