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Nitrate tolerance in angina pectoris.

R Nordlander

    Acta Pharmacologica Et Toxicologica
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Nitrate tolerance is a real clinical issue in angina treatment, affecting various nitrate types. A nitrate-free interval can restore effectiveness and reduce tolerance development.

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    Area of Science:

    • Cardiology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Angina pectoris management often involves nitrates.
    • Nitrate tolerance can limit treatment efficacy.
    • Understanding tolerance mechanisms is crucial for optimal patient care.

    Purpose of the Study:

    • To review current literature on nitrate tolerance in angina treatment.
    • To identify factors influencing nitrate tolerance development.
    • To suggest strategies for mitigating nitrate tolerance.

    Main Methods:

    • Literature review of studies on nitrate tolerance.
    • Analysis of clinical data regarding nitrate formulations and dosing.
    • Synthesis of findings on vascular responsiveness and nitrate-free intervals.

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    Main Results:

    • Nitrate tolerance is a clinically significant phenomenon.
    • Tolerance development is consistent across nitroglycerin, isosorbide-dinitrate, and isosorbide-5-mononitrate.
    • Higher nitrate doses increase the likelihood of tolerance.
    • A nitrate-free interval restores vascular responsiveness.

    Conclusions:

    • Nitrate tolerance is a practical challenge in angina therapy.
    • Optimizing nitrate use with a nitrate-free interval can reduce tolerance.
    • Different nitrate formulations may require tailored dosing strategies.