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Related Experiment Video

Updated: Sep 27, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

[Plasmablastic myeloma initially presented with ascites].

Shuku Sato¹, Shun Tsunoda¹, Wataru Kamata¹

¹Division of Hematology, Shonan Kamakura General Hospital.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology

|April 7, 2022

Summary

This case study highlights a challenging IgG lambda plasmablastic myeloma diagnosis. The patient relapsed quickly and became refractory to novel therapies, emphasizing the need for new treatment strategies.

Keywords:

Ascites Plasmablastic myeloma

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Area of Science:

Hematology
Oncology

Background:

Plasmablastic myeloma is a rare and aggressive plasma cell neoplasm.
Differential diagnosis can be challenging, particularly distinguishing it from plasmablastic lymphoma.

Observation:

A 56-year-old male presented with IgG lambda plasmablastic myeloma and plasmablastic ascites.
The patient underwent autologous stem cell transplantation, achieving minimal residual disease-negative status.
Relapse occurred rapidly (1.5 months), with refractoriness to proteasome inhibitors and daratumumab.

Findings:

The case demonstrates significant chromosomal abnormalities in plasmablastic myeloma.
Rapid relapse and refractoriness to current novel agents pose treatment challenges.

Implications:

Current treatment strategies for plasmablastic myeloma are often insufficient.
There is a critical need for the development of novel therapeutic agents and treatment protocols for this aggressive malignancy.