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Longitudinal changes in lung function in very prematurely born young people receiving high-frequency oscillation or

Alessandra Bisquera1, Christopher Harris2,3, Alan Lunt2,3

  • 1School of Population Health and Environmental Sciences, King's College London, London, UK.

Pediatric Pulmonology
|April 7, 2022
PubMed

Insights

Lung function in extremely premature adolescents showed significant changes over time, regardless of initial ventilation mode. Factors like sex and birth weight, not ventilation strategy, influenced lung health trajectories.

Area of Science:

  • Pediatric Pulmonology
  • Adolescent Health
  • Respiratory Medicine

Background:

  • Extremely premature birth can impact long-term lung development.
  • Understanding lung function changes during adolescence is crucial for this population.

Purpose of the Study:

  • To examine longitudinal changes in lung function in extremely prematurely born adolescents.
  • To determine if initial ventilation mode (high-frequency oscillation vs. conventional ventilation) influences these changes.

Main Methods:

  • Longitudinal follow-up study of adolescents born extremely prematurely.
  • Assessed lung function (FEV1, FVC, DLCO, etc.) at two time points (11-14 and 16-19 years).
  • Compared lung function trajectories between high-frequency oscillation (HFO) and conventional ventilation (CV) groups using mixed models.

Main Results:

  • Significant changes in lung function parameters (FEV1, FVC, DLCO) were observed in both ventilation groups.
  • No significant differences in lung function changes were found between HFO and CV groups.
  • Factors such as male sex, white ethnicity, lower gestational age, and postnatal corticosteroid use were associated with lung function decline.

Conclusions:

  • The mode of ventilation at birth had minimal impact on lung function changes during adolescence.
  • Lung function trajectories are influenced by various factors beyond the initial ventilation strategy.
Abstract

Keywords:
longitudinal changeslung functionprematurityventilation mode

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