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Published on: March 21, 2013
Implanted System for Orthostatic Hypotension in Multiple-System Atrophy
Jordan W Squair1, Maxime Berney1, Mayte Castro Jimenez1
1From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
Abstract:
Orthostatic hypotension is a cardinal feature of multiple-system atrophy. The upright posture provokes syncopal episodes that prevent patients from standing and walking for more than brief periods. We implanted a system to restore regulation of blood pressure and enable a patient with multiple-system atrophy to stand and walk after having lost these abilities because of orthostatic hypotension. This system involved epidural electrical stimulation delivered over the thoracic spinal cord with accelerometers that detected changes in body position. (Funded by the Defitech Foundation.).
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