Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

539
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
539
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

828
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
828
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

36
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
36
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

863
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
863
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

122
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
122
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

3.9K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activity-dependent adaptive deep brain stimulation improves gait in Parkinson's disease.

Nature medicine·2026
Same author

Validating the ADFSCI hypotension symptom domain as a scalable patient reported outcome measure in spinal cord injury.

NPJ digital medicine·2026
Same author

Long-term citrate treatment in high-risk kidney stone formers is not associated with metabolic adverse effects.

Clinical kidney journal·2026
Same author

Frontal subcortical executive dysfunction and minor hallucinations in Parkinson's disease are linked to sensitivity to somatomotor conflicts.

Journal of Parkinson's disease·2026
Same author

Accuracy of dual-energy computed tomography (CT), ultrasound, cone-beam CT, and spectral photon-counting CT for detecting calcium crystal deposition in the osteoarthritic hand: a cross-sectional diagnostic test study.

Scandinavian journal of rheumatology·2026
Same author

[Screening for albuminuria to assess cardiovascular risk].

Revue medicale suisse·2026
Same journal

Sparganosis.

The New England journal of medicine·2026
Same journal

Caring for an Aging America - The Looming Crisis of the Long-Term-Care Workforce.

The New England journal of medicine·2026
Same journal

For Those Left Behind.

The New England journal of medicine·2026
Same journal

Colliding Forces - The Aging of the Baby Boom Generation and Contracting Nursing-Home Supply.

The New England journal of medicine·2026
Same journal

Mandated State-Level Surveillance of Assisted Reproductive Technology - An Emerging Threat in the United States.

The New England journal of medicine·2026
Same journal

Ebola at 50 - Lessons for Outbreak Response and Preparedness.

The New England journal of medicine·2026
See all related articles

Related Experiment Video

Updated: Sep 27, 2025

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
14:09

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

20.9K

Implanted System for Orthostatic Hypotension in Multiple-System Atrophy.

Jordan W Squair1, Maxime Berney1, Mayte Castro Jimenez1

  • 1From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.

The New England Journal of Medicine
|April 7, 2022
PubMed
Summary
This summary is machine-generated.

A novel system using spinal cord stimulation and accelerometers restored blood pressure regulation and mobility in a patient with multiple-system atrophy and severe orthostatic hypotension.

More Related Videos

Home-Based Monitor for Gait and Activity Analysis
07:24

Home-Based Monitor for Gait and Activity Analysis

Published on: August 8, 2019

6.8K
Development of an Algorithm to Perform a Comprehensive Study of Autonomic Dysreflexia in Animals with High Spinal Cord Injury Using a Telemetry Device
06:51

Development of an Algorithm to Perform a Comprehensive Study of Autonomic Dysreflexia in Animals with High Spinal Cord Injury Using a Telemetry Device

Published on: July 29, 2016

8.0K

Related Experiment Videos

Last Updated: Sep 27, 2025

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
14:09

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

20.9K
Home-Based Monitor for Gait and Activity Analysis
07:24

Home-Based Monitor for Gait and Activity Analysis

Published on: August 8, 2019

6.8K
Development of an Algorithm to Perform a Comprehensive Study of Autonomic Dysreflexia in Animals with High Spinal Cord Injury Using a Telemetry Device
06:51

Development of an Algorithm to Perform a Comprehensive Study of Autonomic Dysreflexia in Animals with High Spinal Cord Injury Using a Telemetry Device

Published on: July 29, 2016

8.0K

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Cardiovascular Medicine

Background:

  • Orthostatic hypotension is a primary symptom of multiple-system atrophy, causing debilitating syncopal episodes upon standing.
  • This condition severely limits patients' ability to stand and ambulate, significantly impacting their quality of life.

Purpose of the Study:

  • To develop and test an implantable system for restoring autonomic blood pressure regulation in a patient with multiple-system atrophy.
  • To enable a patient with severe orthostatic hypotension to regain the ability to stand and walk.

Main Methods:

  • Implantation of an epidural electrical stimulation system targeting the thoracic spinal cord.
  • Integration of accelerometers to detect body position changes and modulate stimulation.
  • Closed-loop system designed to restore autonomic control of blood pressure.

Main Results:

  • The system successfully restored blood pressure regulation during postural changes.
  • The patient regained the ability to stand and ambulate independently after system implantation.
  • Demonstrated feasibility of using spinal cord stimulation for orthostatic hypotension in multiple-system atrophy.

Conclusions:

  • Epidural spinal cord stimulation coupled with accelerometers offers a promising therapeutic strategy for orthostatic hypotension in multiple-system atrophy.
  • This innovative approach can significantly improve mobility and independence for affected individuals.
  • Further research is warranted to explore the long-term efficacy and broader applicability of this technology.