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Enhanced diffusivity in microscopically reversible active matter.

Artem Ryabov1,2,3, Mykola Tasinkevych2,3,4

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Microscopic reversibility (MR) in self-propelled enzymes enhances particle mobility and diffusion coefficients. This finding helps explain high observed diffusivities in nanoswimmers, even under external forces.

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Area of Science:

  • Physics of self-propelled objects
  • Nanoscale science
  • Chemical kinetics

Background:

  • Experimental studies increasingly focus on individual catalytic enzyme motion.
  • Theoretical understanding of nanoscale self-propulsion mechanisms, especially high enzyme diffusivities, remains limited.

Purpose of the Study:

  • To investigate the impact of microscopic reversibility (MR) on the self-propulsion of nanoscale objects.
  • To theoretically explain the origins of high diffusion coefficients observed in individual enzymes.
  • To assess the influence of external forces on enzyme mobility.

Main Methods:

  • Theoretical modeling based on the principle of microscopic reversibility (MR).
  • Analysis of particle dynamics and diffusion coefficients, comparing MR-included and MR-neglected scenarios.
  • Inclusion of external force effects in the theoretical framework.

Main Results:

  • Microscopic reversibility (MR) significantly increases particle mobility and diffusion coefficients compared to models neglecting MR.
  • Diffusion coefficients are further enhanced by the action of external forces.
  • The study provides a theoretical basis for understanding enhanced enzyme diffusivity.

Conclusions:

  • Microscopic reversibility is a crucial factor in the active motion of individual nanoswimmers.
  • The findings offer a new perspective for interpreting experimental measurements of enzyme diffusivity.
  • The relevance of MR for active nanoscale motion can be further tested using these theoretical insights.