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Paradoxical effects of amitriptyline on borderline patients

P H Soloff, A George, R S Nathan

The American Journal of Psychiatry

|December 1, 1986

Abstract:

A paradoxical increase in suicide threats, paranoid ideation, and demanding and assaultive behavior occurred among 15 borderline inpatients receiving amitriptyline in a double-blind study. This pattern differed significantly from that of 14 nonresponding patients receiving placebo.

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