A multifunctional 3D dressing unit based on the core-shell hydrogel microfiber for diabetic foot wound healing

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• 3D Printing Technology

Background:

• Diabetic foot wound healing is complex, often requiring advanced treatments beyond single-function dressings.
• Current treatments face challenges in effectively managing the multifaceted nature of these wounds.

Purpose of the Study:

• To develop and evaluate a novel, multifunctional medical dressing for diabetic foot wound healing.
• To utilize coaxial biological 3D printing for creating advanced hydrogel-based dressings.

Main Methods:

• Coaxial biological 3D printing of core-shell hydrogel fibers to create multifunctional dressings.
• In vivo assessment of the dressing's efficacy in type 2 diabetic rats over 14 days, comparing against gauze.
• Evaluation of biocompatibility, drug release, water absorption, antibacterial, and anti-inflammatory properties.

Main Results:

• The 3D-printed dressing demonstrated good biocompatibility, controlled drug release, and excellent water management.
• Significant reduction in inflammation and promotion of blood vessel, hair follicle, and collagen fiber formation observed.
• Increased post-healing granulation tissue thickness compared to the gauze control.

Conclusions:

• The developed multifunctional 3D-printed dressing effectively promotes diabetic foot wound healing.
• The dressing's properties suggest suitability for clinical applications in managing complex diabetic wounds.