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Regulatory elements can be essential for maintaining broad chromatin organization and cell viability

Ying Liu1, Bo Ding2, Lina Zheng3

  • 1Biomedical Pioneering Innovation Center, Beijing Advanced Innovation Center for Genomics, Peking-Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.

Nucleic Acids Research
|April 7, 2022
PubMed
Summary

Active promoters and enhancers, known as hotspots, are crucial for maintaining broad chromatin organization and cell fitness. Their essentiality arises from regulating multiple non-essential genes, impacting cell survival.

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