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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

849
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
849
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

379
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
379

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Opioid Consumption Trends in Resurfaced versus Unresurfaced Patellae in Total Knee Arthroplasty.

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Related Experiment Video

Updated: Sep 27, 2025

Author Spotlight: Minimally Invasive Ultrasound-Guided Acupotomy in Knee Osteoarthritis Treatment
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Author Spotlight: Minimally Invasive Ultrasound-Guided Acupotomy in Knee Osteoarthritis Treatment

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Topical Cannabidiol (CBD) After Total Knee Arthroplasty Does Not Decrease Pain or Opioid Use: A Prospective

Amer Haffar1, Irfan A Khan1, Mohammad S Abdelaal1

  • 1Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA.

The Journal of Arthroplasty
|April 7, 2022
PubMed
Summary
This summary is machine-generated.

Topical cannabidiol (CBD) did not improve pain, sleep, or opioid use after total knee arthroplasty (TKA). This study found no additional analgesic benefits of CBD when used with standard multimodal pain management following TKA.

Keywords:
analgesiacannabidiol (CBD)cannabisopioidtotal knee arthroplasty

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Area of Science:

  • Orthopedic Surgery
  • Pain Management
  • Pharmacology

Background:

  • Multimodal analgesia is standard for total knee arthroplasty (TKA).
  • Topical cannabidiol (CBD) is increasingly used postoperatively.
  • The study evaluated topical CBD's analgesic effects after primary TKA.

Purpose of the Study:

  • To analyze the analgesic benefits of topical CBD following primary TKA.
  • To determine if topical CBD supplements multimodal analgesia effectively.
  • To assess CBD's impact on pain, sleep, and opioid consumption post-TKA.

Main Methods:

  • Randomized double-blinded placebo-controlled trial with 80 patients undergoing primary unilateral TKA.
  • Four groups: topical CBD, essential oil (EO), CBD + EO, or placebo (PLA), applied thrice daily for two weeks.
  • Outcomes: Visual Analog Scale (VAS) pain, Numeric Rating Scale (NRS) sleep scores, and 42-day cumulative opioid use.

Main Results:

  • No statistically significant differences in VAS pain scores, NRS sleep scores, or opioid use between groups at any time point.
  • The CBD cohort showed higher VAS pain scores on postoperative day 2 compared to the EO cohort (P=.013).
  • Demographics and preoperative scores were similar across all four cohorts.

Conclusions:

  • Topical CBD did not reduce pain or opioid consumption post-TKA.
  • CBD supplementation did not improve sleep scores following total knee arthroplasty.
  • Local application of topical CBD offers no additional pain relief benefits after TKA when used with standard multimodal analgesia.