Colorectal Sessile Serrated Lesion Detection Using Linked Color Imaging: A Multicenter, Parallel Randomized...

Area of Science:

• Gastroenterology
• Endoscopy
• Medical Imaging Technology

Background:

• Colorectal cancer screening relies on effective detection of precancerous lesions.
• Sessile serrated lesions (SSLs) are often missed with conventional white light imaging (WLI).
• Linked color imaging (LCI) is a new technology designed to enhance visualization of mucosal differences.

Purpose of the Study:

• To compare the efficacy of LCI versus WLI in detecting colorectal sessile serrated lesions (SSLs).
• To evaluate the impact of LCI on overall polyp and adenoma detection rates.

Main Methods:

• A large-scale, multicenter, prospective randomized controlled trial.
• 884 patients were randomized into either the LCI group or the WLI group.
• The primary endpoint was the SSL detection rate (SDR).

Main Results:

• The SSL detection rate was significantly higher in the LCI group (11.3%) compared to the WLI group (5.9%) (P = .004).
• LCI also led to significantly higher detection rates for overall polyps, adenomas, and diminutive/flat lesions.
• Multivariate analysis identified LCI as an independent factor for increased SDR.

Conclusions:

• Linked color imaging (LCI) demonstrates superior performance for detecting SSLs compared to WLI.
• LCI may improve the detection of polyps and adenomas during colonoscopy.
• LCI is recommended as a valuable tool for routine colonoscopic examinations.