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Cell Migration

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.

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Related Experiment Video

Updated: Sep 27, 2025

Generation of Multicue Cellular Microenvironments by UV-Photopatterning of Three-Dimensional Cell Culture Substrates

Generation of Multicue Cellular Microenvironments by UV-Photopatterning of Three-Dimensional Cell Culture Substrates

Published on: June 2, 2022

Programmed Topographic Substrates for Studying Roughness Gradient-Dependent Cell Migration Using Two-Photon

Subhashree Shivani¹, Yu-Hsiang Hsu¹, Cheng-Je Lee¹

¹Institute of Applied Mechanics, National Taiwan University, Taipei, Taiwan.

Frontiers in Cell and Developmental Biology

|April 8, 2022

Summary

This summary is machine-generated.

Researchers explored roughness-dependent topotaxis, finding that MG63 cells migrate faster on rougher surfaces and prefer moving from high to low roughness areas. Surface roughness and gradient steepness influence cell migration.

Keywords:

alignotaxis cell migration contact guidance topotaxis two-photon polymerization

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Last Updated: Sep 27, 2025

Generation of Multicue Cellular Microenvironments by UV-Photopatterning of Three-Dimensional Cell Culture Substrates

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Published on: June 2, 2022

Study of Cell Migration in Microfabricated Channels

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Published on: February 21, 2014

Control of Cell Geometry through Infrared Laser Assisted Micropatterning

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Published on: July 10, 2021

Area of Science:

Biomaterials Science
Cell Biology
Surface Engineering

Background:

Extracellular matrix properties like stiffness and adhesiveness guide cell migration (durotaxis, haptotaxis).
Topotaxis, or contact guidance by surface topography, is less understood.
Existing topotaxis studies often use photolithography for uniform structures.

Purpose of the Study:

To investigate roughness-dependent topotaxis as a novel cell migration cue.
To develop a new method for fabricating substrates with controlled surface roughness.
To analyze how MG63 cell migration is affected by varying surface roughness patterns.

Main Methods:

Fabrication of substrates with tunable surface roughness (0.29–1.11 μm) using two-photon polymerization by controlling voxel distance.
Transfer of patterned Ormocomp masters to polypropylene films via nanoimprinting.
Experimental observation and analysis of MG63 cell migration on fabricated surfaces.

Main Results:

MG63 cell migration velocity increases with substrate roughness.
Cells exhibit a preference for migrating from higher to lower roughness regions, with decreasing velocity.
Migration velocity remained constant on lower roughness ranges of steep gradients, indicating gradient steepness as a cue.

Conclusions:

Surface roughness and roughness gradient steepness are significant environmental cues influencing cell migration.
The developed two-photon polymerization and nanoimprint technique offers a novel approach for fabricating complex 3D structures for topotaxis studies.
This methodology advances the exploration of topotactic cell migration and biomaterial design.